Activation of neutrophils by recombinant interleukin 6

L Borish, R Rosenbaum, L Albury, S Clark - Cellular immunology, 1989 - Elsevier
Abstract The cytokine interleukin 6 (IL-6) has been shown to have multiple biological
activities against many cellular targets. The present studies were designed to determine
whether these activities extended to the neutrophil (PMN). Initially, we investigated the ability
of IL-6 to modulate PMN-mediated antibody-dependent cellular cytotoxicity. The presence of
IL-6 stimulated 51 Cr release from labeled, opsonized targets by 67.1%(from 21.6±1.4% to
36.1±1.3% at 10 U of IL-6 (P< 0.01)). IL-6 was not directly toxic to the target cells and …