Beta-adrenergic receptors, from their discovery and characterization through their manipulation to beneficial clinical application
SB Wachter, EM Gilbert - Cardiology, 2012 - karger.com
SB Wachter, EM Gilbert
Cardiology, 2012•karger.comAbstract β-Adrenergic receptors (β-AR) are central to the overall regulation of cardiac
function. From the first proposed receptor/transmitter concept to the latest clinical β-blocker
trials β-AR have been shown to play an important role in cardiac disease and heart failure in
particular. This study provides a historical perspective, reviews the latest discoveries and
beliefs, and discusses the current clinical practices of β-AR and their modulation with their
associated guanine-nucleotide regulatory protein/adenylylcyclasesignal transduction …
function. From the first proposed receptor/transmitter concept to the latest clinical β-blocker
trials β-AR have been shown to play an important role in cardiac disease and heart failure in
particular. This study provides a historical perspective, reviews the latest discoveries and
beliefs, and discusses the current clinical practices of β-AR and their modulation with their
associated guanine-nucleotide regulatory protein/adenylylcyclasesignal transduction …
Abstract
β-Adrenergic receptors (β-AR) are central to the overall regulation of cardiac function. From the first proposed receptor/transmitter concept to the latest clinical β-blocker trials β-AR have been shown to play an important role in cardiac disease and heart failure in particular. This study provides a historical perspective, reviews the latest discoveries and beliefs, and discusses the current clinical practices of β-AR and their modulation with their associated guanine-nucleotide regulatory protein/adenylylcyclasesignal transduction pathways.
Karger