One of the hallmarks of cancer is the ability to generate and withstand unusual levels of
oxidative stress. In part, this property of tumor cells is conferred by elevation of the cellular
redox buffer glutathione. Though enzymes of the glutathione synthesis and salvage
pathways have been characterized for several decades, we still lack a comprehensive
understanding of their independent and coordinate regulatory mechanisms. Recent studies
have further revealed that overall central metabolic pathways are frequently altered in …