[HTML][HTML] 3, 4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome
Y He, S Varadarajan, R Muñoz-Planillo… - Journal of Biological …, 2014 - ASBMB
The NLRP3 inflammasome is a critical component of the innate immune system. NLRP3
activation is induced by diverse stimuli associated with bacterial infection or tissue damage,
but its inappropriate activation is involved in the pathogenesis of inherited and acquired
inflammatory diseases. However, the mechanism by which NLRP3 is activated remains
poorly understood. In this study, we explored the role of kinases in NLRP3 inflammasome
activation by screening a kinase inhibitor library and identified 3, 4-methylenedioxy-β …
activation is induced by diverse stimuli associated with bacterial infection or tissue damage,
but its inappropriate activation is involved in the pathogenesis of inherited and acquired
inflammatory diseases. However, the mechanism by which NLRP3 is activated remains
poorly understood. In this study, we explored the role of kinases in NLRP3 inflammasome
activation by screening a kinase inhibitor library and identified 3, 4-methylenedioxy-β …