[HTML][HTML] Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene

DH Zhang, L Cohn, P Ray, K Bottomly, A Ray - Journal of Biological …, 1997 - ASBMB
Interleukin-5 (IL-5), which is produced by CD4+ T helper 2 (Th2) cells, but not by Th1 cells,
plays a key role in the development of eosinophilia in asthma. Despite increasing evidence
that the outcome of many diseases is determined by the ratio of the two subsets of CD4+ T
helper cells, Th1 and Th2, the molecular basis for Th1-and Th2-specific gene expression
remains to be elucidated. We previously established a critical role for the transcription factor
GATA-3 in IL-5 promoter activation in EL-4 cells, which express both Th1-and Th2-type …