A pilot study showing associations between frequency of CD4+ memory cell subsets at diagnosis and duration of partial remission in type 1 diabetes
In some patients with type 1 diabetes the dose of insulin required to achieve euglycemia is
substantially reduced soon after diagnosis. This partial remission is associated with β-cell
function and good glucose control. The purpose of this study was to assess whether
frequencies of CD4+ T cell subsets in children newly diagnosed with type 1 diabetes are
associated with length of partial remission. We found that the frequency of CD4+ memory
cells, activated Treg cells and CD25+ cells that express a high density of the IL-7 receptor …
substantially reduced soon after diagnosis. This partial remission is associated with β-cell
function and good glucose control. The purpose of this study was to assess whether
frequencies of CD4+ T cell subsets in children newly diagnosed with type 1 diabetes are
associated with length of partial remission. We found that the frequency of CD4+ memory
cells, activated Treg cells and CD25+ cells that express a high density of the IL-7 receptor …