A phase II randomized vehicle-controlled trial of intradermal allogeneic fibroblasts for recessive dystrophic epidermolysis bullosa
SS Venugopal, W Yan, JW Frew, HI Cohn… - Journal of the American …, 2013 - Elsevier
Background Chronic wounds are a major source of morbidity and mortality in generalized
severe recessive dystrophic epidermolysis bullosa (RDEB-GS). Objective This was a phase
II double-blinded randomized controlled trial of intralesional allogeneic cultured fibroblasts
in suspension solution versus suspension solution alone for wound healing in RDEB-GS.
Methods Adult patients with RDEB-GS were screened for chronic ulcers and reduced
collagen VII expression. Up to 6 pairs of symmetric wounds were measured and biopsied at …
severe recessive dystrophic epidermolysis bullosa (RDEB-GS). Objective This was a phase
II double-blinded randomized controlled trial of intralesional allogeneic cultured fibroblasts
in suspension solution versus suspension solution alone for wound healing in RDEB-GS.
Methods Adult patients with RDEB-GS were screened for chronic ulcers and reduced
collagen VII expression. Up to 6 pairs of symmetric wounds were measured and biopsied at …