Dual mechanism of type VII collagen transfer by bone marrow mesenchymal stem cell extracellular vesicles to recessive dystrophic epidermolysis bullosa fibroblasts
JD McBride, L Rodriguez-Menocal, A Candanedo… - Biochimie, 2018 - Elsevier
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe blistering disease resulting
from a lack of type VII collagen production. Recent clinical trials have shown efficacy of bone
marrow-derived mesenchymal stem cells (BM-MSCs) in the treatment of epidermolysis
bullosa, including improved basement membrane restructuring and cutaneous wound
healing. The mechanism as to how type VII collagen is transferred from donor stem cell to
recipient RDEB cells has not been defined. Here, we submit the model that BM-MSC …
from a lack of type VII collagen production. Recent clinical trials have shown efficacy of bone
marrow-derived mesenchymal stem cells (BM-MSCs) in the treatment of epidermolysis
bullosa, including improved basement membrane restructuring and cutaneous wound
healing. The mechanism as to how type VII collagen is transferred from donor stem cell to
recipient RDEB cells has not been defined. Here, we submit the model that BM-MSC …