Targeting ROCK signaling in health, malignant and non-malignant diseases
R Shahbazi, B Baradaran, M Khordadmehr, S Safaei… - Immunology letters, 2020 - Elsevier
A Rho-associated coiled-coil kinase (ROCK) is identified as a critical downstream effector of
GTPase RhoA which contains two isoforms, ROCK1 (also known as p160ROCK and ROKβ)
and ROCK2 (also known as Rho-kinase and ROKα), the gene of which is placed on
chromosomes 18 (18q11. 1) and 2 (2p24), respectively. ROCKs have a principal function in
the generation of actin-myosin contractility and regulation of actin cytoskeleton dynamics.
They represent a chief role in regulating various cellular functions, such as apoptosis …
GTPase RhoA which contains two isoforms, ROCK1 (also known as p160ROCK and ROKβ)
and ROCK2 (also known as Rho-kinase and ROKα), the gene of which is placed on
chromosomes 18 (18q11. 1) and 2 (2p24), respectively. ROCKs have a principal function in
the generation of actin-myosin contractility and regulation of actin cytoskeleton dynamics.
They represent a chief role in regulating various cellular functions, such as apoptosis …