Importance Sepsis is a heterogeneous syndrome. Identification of distinct clinical
phenotypes may allow more precise therapy and improve care. Objective To derive sepsis
phenotypes from clinical data, determine their reproducibility and correlation with host-
response biomarkers and clinical outcomes, and assess the potential causal relationship
with results from randomized clinical trials (RCTs). Design, Settings, and Participants
Retrospective analysis of data sets using statistical, machine learning, and simulation tools …