Context The pathogenesis of depression is not fully understood, but studies suggest that low-
grade systemic inflammation contributes to the development of depression. Objective To test
whether elevated plasma levels of C-reactive protein (CRP) are associated with
psychological distress and depression. Design We performed cross-sectional and
prospective analyses of CRP levels in 4 clinically relevant categories using data from 2
general population studies. Setting The Copenhagen General Population and the …