[HTML][HTML] Silencing of solute carrier family 13 member 5 disrupts energy homeostasis and inhibits proliferation of human hepatocarcinoma cells
The solute carrier family 13 member 5 (SLC13A5), a sodium-coupled citrate transporter,
plays a key role in importing citrate from the circulation into liver cells. Recent evidence has
revealed that SLC13A5 deletion protects mice from high-fat diet–induced hepatic steatosis
and that mutation of the SLC13A5 orthologues in Drosophila melanogaster and
Caenorhabditis elegans promotes longevity. However, despite the emerging importance of
SLC13A5 in energy homeostasis, whether perturbation of SLC13A5 affects the metabolism …
plays a key role in importing citrate from the circulation into liver cells. Recent evidence has
revealed that SLC13A5 deletion protects mice from high-fat diet–induced hepatic steatosis
and that mutation of the SLC13A5 orthologues in Drosophila melanogaster and
Caenorhabditis elegans promotes longevity. However, despite the emerging importance of
SLC13A5 in energy homeostasis, whether perturbation of SLC13A5 affects the metabolism …