ContextExcessive calorie intake and subsequent obesity increases the risk of developing
chronic disease and decreases life expectancy. In rodent models, calorie restriction with
adequate nutrient intake decreases the risk of developing chronic disease and extends
maximum life span. ObjectiveTo evaluate the physiological and clinical implications of
calorie restriction with adequate nutrient intake. Evidence AcquisitionSearch of PubMed
(1966-December 2006) using terms encompassing various aspects of calorie restriction …