[HTML][HTML] Maternal lipid metabolism directs fetal liver programming following nutrient stress
CE Bowman, ESS Alpergin, K Cavagnini, DM Smith… - Cell reports, 2019 - cell.com
CE Bowman, ESS Alpergin, K Cavagnini, DM Smith, S Scafidi, MJ Wolfgang
Cell reports, 2019•cell.comThe extreme metabolic demands of pregnancy require coordinated metabolic adaptations
between mother and fetus to balance fetal growth and maternal health with nutrient
availability. To determine maternal and fetal contributions to metabolic flexibility during
gestation, pregnant mice with genetic impairments in mitochondrial carbohydrate and/or
lipid metabolism were subjected to nutrient deprivation. The maternal fasting response
initiates a fetal liver transcriptional program marked by upregulation of lipid-and peroxisome …
between mother and fetus to balance fetal growth and maternal health with nutrient
availability. To determine maternal and fetal contributions to metabolic flexibility during
gestation, pregnant mice with genetic impairments in mitochondrial carbohydrate and/or
lipid metabolism were subjected to nutrient deprivation. The maternal fasting response
initiates a fetal liver transcriptional program marked by upregulation of lipid-and peroxisome …
Summary
The extreme metabolic demands of pregnancy require coordinated metabolic adaptations between mother and fetus to balance fetal growth and maternal health with nutrient availability. To determine maternal and fetal contributions to metabolic flexibility during gestation, pregnant mice with genetic impairments in mitochondrial carbohydrate and/or lipid metabolism were subjected to nutrient deprivation. The maternal fasting response initiates a fetal liver transcriptional program marked by upregulation of lipid- and peroxisome proliferator-activated receptor alpha (Pparα)-regulated genes. Impaired maternal lipid metabolism alters circulating lipid metabolite concentrations and enhances the fetal response to fasting, which is largely dependent on fetal Pparα. Maternal fasting also improves metabolic deficits in fetal carbohydrate metabolism by increasing the availability of alternative substrates. Impairment of both carbohydrate and lipid metabolism in pregnant dams further exacerbates the fetal liver transcriptional response to nutrient deprivation. Together, these data demonstrate a regulatory role for mitochondrial macronutrient metabolism in mediating maternal-fetal metabolic communication, particularly when nutrients are limited.
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