The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET

WE Klunk, RA Koeppe, JC Price, TL Benzinger… - Alzheimer's & …, 2015 - Elsevier
Although amyloid imaging with PiB-PET ([C-11] Pittsburgh Compound-B positron emission
tomography), and now with F-18-labeled tracers, has produced remarkably consistent
qualitative findings across a large number of centers, there has been considerable variability
in the exact numbers reported as quantitative outcome measures of tracer retention. In some
cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of
course, different tracers yield different numbers. Our working group was formed to …