Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models
MA Busche, C Grienberger, AD Keskin, B Song… - Nature …, 2015 - nature.com
Nature neuroscience, 2015•nature.com
Among the most promising approaches for treating Alzheimer´ s disease is immunotherapy
with amyloid-β (Aβ)-targeting antibodies. Using in vivo two-photon imaging in mouse
models, we found that two different antibodies to Aβ used for treatment were ineffective at
repairing neuronal dysfunction and caused an increase in cortical hyperactivity. This
unexpected finding provides a possible cellular explanation for the lack of cognitive
improvement by immunotherapy in human studies.
with amyloid-β (Aβ)-targeting antibodies. Using in vivo two-photon imaging in mouse
models, we found that two different antibodies to Aβ used for treatment were ineffective at
repairing neuronal dysfunction and caused an increase in cortical hyperactivity. This
unexpected finding provides a possible cellular explanation for the lack of cognitive
improvement by immunotherapy in human studies.
Abstract
Among the most promising approaches for treating Alzheimer´s disease is immunotherapy with amyloid-β (Aβ)-targeting antibodies. Using in vivo two-photon imaging in mouse models, we found that two different antibodies to Aβ used for treatment were ineffective at repairing neuronal dysfunction and caused an increase in cortical hyperactivity. This unexpected finding provides a possible cellular explanation for the lack of cognitive improvement by immunotherapy in human studies.
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