[HTML][HTML] Alarmins: awaiting a clinical response

JK Chan, J Roth, JJ Oppenheim… - The Journal of …, 2012 - Am Soc Clin Investig
JK Chan, J Roth, JJ Oppenheim, KJ Tracey, T Vogl, M Feldmann, N Horwood, J Nanchahal
The Journal of clinical investigation, 2012Am Soc Clin Investig
Alarmins are endogenous molecules that are constitutively available and released upon
tissue damage and activate the immune system. Current evidence indicates that
uncontrolled and excessive release of alarmins contributes to the dysregulated processes
seen in many inflammatory and autoimmune conditions, as well as tumorigenesis and
cancer spread. Conversely, alarmins have also been found to play a major role in the
orchestration of tissue homeostasis, including repair and remodeling in the heart, skin, and …
Alarmins are endogenous molecules that are constitutively available and released upon tissue damage and activate the immune system. Current evidence indicates that uncontrolled and excessive release of alarmins contributes to the dysregulated processes seen in many inflammatory and autoimmune conditions, as well as tumorigenesis and cancer spread. Conversely, alarmins have also been found to play a major role in the orchestration of tissue homeostasis, including repair and remodeling in the heart, skin, and nervous system. Here, we provide an update and overview on alarmins, highlighting the areas that may benefit from this clinical translation.
The Journal of Clinical Investigation