[HTML][HTML] Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-In silico Approach Combining In vitro Experiments and Machine Learning
E Zechendorf, P Vaßen, J Zhang, A Hallawa… - Frontiers in …, 2018 - frontiersin.org
Life-threatening cardiomyopathy is a severe, but common, complication associated with
severe trauma or sepsis. Several signaling pathways involved in apoptosis and necroptosis
are linked to trauma-or sepsis-associated cardiomyopathy. However, the underling
causative factors are still debatable. Heparan sulfate (HS) fragments belong to the class of
danger/damage-associated molecular patterns liberated from endothelial-bound
proteoglycans by heparanase during tissue injury associated with trauma or sepsis. We …
severe trauma or sepsis. Several signaling pathways involved in apoptosis and necroptosis
are linked to trauma-or sepsis-associated cardiomyopathy. However, the underling
causative factors are still debatable. Heparan sulfate (HS) fragments belong to the class of
danger/damage-associated molecular patterns liberated from endothelial-bound
proteoglycans by heparanase during tissue injury associated with trauma or sepsis. We …
[CITATION][C] Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-In silico Approach Combining In vitro Experiments and Machine Learning …
E Zechendorf, P Vaßen, J Zhang, A Hallawa… - 2018 - vitro