MicroRNA-199a-5p is associated with hypoxia-inducible factor-1α expression in lungs from patients with COPD
S Mizuno, HJ Bogaard, J Gomez-Arroyo, A Alhussaini… - Chest, 2012 - Elsevier
Background MicroRNAs (miRNAs) are small noncoding RNAs that silence target gene
expression posttranscriptionally, and their impact on gene expression has been reported in
various diseases. It has been reported that the expression of the hypoxia-inducible factor-1α
(HIF-1α) is reduced and that of p53 is increased in lungs from patients with COPD. However,
the role of miRNAs associated with these genes in lungs from patients with COPD is
unknown. Methods Lung tissue samples from 55 patients were included in this study. Total …
expression posttranscriptionally, and their impact on gene expression has been reported in
various diseases. It has been reported that the expression of the hypoxia-inducible factor-1α
(HIF-1α) is reduced and that of p53 is increased in lungs from patients with COPD. However,
the role of miRNAs associated with these genes in lungs from patients with COPD is
unknown. Methods Lung tissue samples from 55 patients were included in this study. Total …