Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research
Why does a constant barrage of DNA damage lead to disease in some individuals, while
others remain healthy? This article surveys current work addressing the implications of inter-
individual variation in DNA repair capacity for human health, and discusses the status of
DNA repair assays as potential clinical tools for personalized prevention or treatment of
disease. In particular, we highlight research showing that there are significant inter-
individual variations in DNA repair capacity (DRC), and that measuring these differences …
others remain healthy? This article surveys current work addressing the implications of inter-
individual variation in DNA repair capacity for human health, and discusses the status of
DNA repair assays as potential clinical tools for personalized prevention or treatment of
disease. In particular, we highlight research showing that there are significant inter-
individual variations in DNA repair capacity (DRC), and that measuring these differences …