[HTML][HTML] Epigenetic alterations are associated with gastric emptying disturbances in diabetes mellitus
SP Narayanan, JH Lee, A Bhagwate… - Clinical and …, 2020 - journals.lww.com
METHODS: Using the ChIP-seq (chromatin immunoprecipitation combined with next-
generation sequencing) assays, we compared the genome-wide enrichment of 3 histone
modifications (ie, H3K4me3, H3K9ac, and H3K27ac) in buffy coats from 20 diabetic patients
with gastrointestinal symptoms and normal (n= 6), delayed (n= 8), or rapid (n= 6) GE.
RESULTS: Between patients with DM with delayed vs normal GE, there were 108 and 54
genes that were differentially bound (false discovery rate< 0.05) with H3K27ac and H3K9ac …
generation sequencing) assays, we compared the genome-wide enrichment of 3 histone
modifications (ie, H3K4me3, H3K9ac, and H3K27ac) in buffy coats from 20 diabetic patients
with gastrointestinal symptoms and normal (n= 6), delayed (n= 8), or rapid (n= 6) GE.
RESULTS: Between patients with DM with delayed vs normal GE, there were 108 and 54
genes that were differentially bound (false discovery rate< 0.05) with H3K27ac and H3K9ac …