Prostaglandin E2-dependent IL-23 production in aged murine dendritic cells
RG Myer, R El Mezayen, KP High - Experimental gerontology, 2010 - Elsevier
CD4+ T cells of the Th17 subtype are over-represented in the aged immune system.
Dendritic cells (DC) play a critical role in naïve CD4+ T cell differentiation. However,
expression of cytokines by aged DC that promote differentiation or survival of Th17 cells has
not been extensively investigated. Using bone marrow-derived DC from C57BL/6 mice of
different ages we compared cytokine production after DC activation by Toll-like receptor
agonists for TLR4 and/or TLR7/8. DC-derived TNF-α and IL-12p70 production and …
Dendritic cells (DC) play a critical role in naïve CD4+ T cell differentiation. However,
expression of cytokines by aged DC that promote differentiation or survival of Th17 cells has
not been extensively investigated. Using bone marrow-derived DC from C57BL/6 mice of
different ages we compared cytokine production after DC activation by Toll-like receptor
agonists for TLR4 and/or TLR7/8. DC-derived TNF-α and IL-12p70 production and …