Possible Mechanisms Of Emphysema in Smokers: In Vitro Suppression of Serum Elastase-lnhibitory Capacity by Fresh Cigarette Smoke and its Prevention by …
H Carp, A Janoff - American Review of Respiratory Disease, 1978 - atsjournals.org
H Carp, A Janoff
American Review of Respiratory Disease, 1978•atsjournals.orgFreshly prepared, aqueous solutions of cigarette smoke suppressed the elastase-inhibitory
capacity of human serum. Immunoelectrophoresis of mixtures of aqueous smoke solution,
human serum, and pancreatic elastase showed decreased elastase/alpha1-proteinase
inhibitor complexes and increased free, active protease. Phenolic antioxidants prevented
the suppression of serum elastase-inhibition by cigarette smoke. By contrast, treatment of
serum with model oxidants caused a similar suppression of elastase inhibition. These …
capacity of human serum. Immunoelectrophoresis of mixtures of aqueous smoke solution,
human serum, and pancreatic elastase showed decreased elastase/alpha1-proteinase
inhibitor complexes and increased free, active protease. Phenolic antioxidants prevented
the suppression of serum elastase-inhibition by cigarette smoke. By contrast, treatment of
serum with model oxidants caused a similar suppression of elastase inhibition. These …
Freshly prepared, aqueous solutions of cigarette smoke suppressed the elastase-inhibitory capacity of human serum. Immunoelectrophoresis of mixtures of aqueous smoke solution, human serum, and pancreatic elastase showed decreased elastase/alpha1-proteinase inhibitor complexes and increased free, active protease. Phenolic antioxidants prevented the suppression of serum elastase-inhibition by cigarette smoke. By contrast, treatment of serum with model oxidants caused a similar suppression of elastase inhibition. These results suggested that emphysema in cigarette smokers might be due, in part, to the local suppression of alpha1-proteinase inhibitor in lung by oxidizing agents present in cigarette smoke.
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