Autoinflammation and autoimmunity in systemic juvenile idiopathic arthritis
PA Nigrovic - Proceedings of the National Academy of …, 2015 - National Acad Sciences
Proceedings of the National Academy of Sciences, 2015•National Acad Sciences
Juvenile idiopathic arthritis (JIA) encompasses a range of phenotypes of joint inflammation
that begin in childhood. The most distinctive and potentially most severe of these is systemic
JIA (sJIA), an intensely inflammatory disease characterized by high spiking fevers and
evanescent rashes that sometimes progresses to a devastating chronic polyarthritis. In
PNAS, Ombrello et al. establish an unequivocal genetic association between sJIA and the
major histocompatibility (MHC) region, in particular with the class II allele HLA-DRB1* 11 (1) …
that begin in childhood. The most distinctive and potentially most severe of these is systemic
JIA (sJIA), an intensely inflammatory disease characterized by high spiking fevers and
evanescent rashes that sometimes progresses to a devastating chronic polyarthritis. In
PNAS, Ombrello et al. establish an unequivocal genetic association between sJIA and the
major histocompatibility (MHC) region, in particular with the class II allele HLA-DRB1* 11 (1) …
Juvenile idiopathic arthritis (JIA) encompasses a range of phenotypes of joint inflammation that begin in childhood. The most distinctive and potentially most severe of these is systemic JIA (sJIA), an intensely inflammatory disease characterized by high spiking fevers and evanescent rashes that sometimes progresses to a devastating chronic polyarthritis. In PNAS, Ombrello et al. establish an unequivocal genetic association between sJIA and the major histocompatibility (MHC) region, in particular with the class II allele HLA-DRB1* 11 (1). This is a big deal. Let’s consider why.
National Acad Sciences