Alternative activation in systemic juvenile idiopathic arthritis monocytes
C Macaubas, KD Nguyen, A Peck, J Buckingham… - Clinical …, 2012 - Elsevier
Systemic juvenile idiopathic arthritis (SJIA) is a chronic autoinflammatory condition. The
association with macrophage activation syndrome, and the therapeutic efficacy of inhibiting
monocyte-derived cytokines, has implicated these cells in SJIA pathogenesis. To
characterize the activation state (classical/M1 vs. alternative/M2) of SJIA monocytes, we
immunophenotyped monocytes using several approaches. Monocyte transcripts were
analyzed by microarray and quantitative PCR. Surface proteins were measured at the single …
association with macrophage activation syndrome, and the therapeutic efficacy of inhibiting
monocyte-derived cytokines, has implicated these cells in SJIA pathogenesis. To
characterize the activation state (classical/M1 vs. alternative/M2) of SJIA monocytes, we
immunophenotyped monocytes using several approaches. Monocyte transcripts were
analyzed by microarray and quantitative PCR. Surface proteins were measured at the single …