[HTML][HTML] Calcineurin signaling regulates human islet β-cell survival
SA Soleimanpour, MF Crutchlow, AM Ferrari… - Journal of Biological …, 2010 - ASBMB
The calcium-regulated phosphatase calcineurin intersects with both calcium and cAMP-
mediated signaling pathways in the pancreatic β-cell. Pharmacologic calcineurin inhibition,
necessary to prevent rejection in the setting of organ transplantation, is associated with post-
transplant β-cell failure. We sought to determine the effect of calcineurin inhibition on β-cell
replication and survival in rodents and in isolated human islets. Further, we assessed
whether the GLP-1 receptor agonist and cAMP stimulus, exendin-4 (Ex-4), could rescue β …
mediated signaling pathways in the pancreatic β-cell. Pharmacologic calcineurin inhibition,
necessary to prevent rejection in the setting of organ transplantation, is associated with post-
transplant β-cell failure. We sought to determine the effect of calcineurin inhibition on β-cell
replication and survival in rodents and in isolated human islets. Further, we assessed
whether the GLP-1 receptor agonist and cAMP stimulus, exendin-4 (Ex-4), could rescue β …