Tumor-host interaction: analysis of cytokines, growth factors, and tumorinfiltrating lymphocytes in ovarian carcinomas

AJ Merogi, AJ Marrogi, R Ramesh, WR Robinson… - Human pathology, 1997 - Elsevier
The host-tumor interaction may play an important role in determining tumor progress. Recent
studies have shown that this interaction can be influenced by the release of soluble factors
by tumor cells and tumor-infiltrating lymphocytes (TIL). The aim of our study is to characterize
the nature of cytokines and growth factors and their relationship to the cellular infiltrates in
16 patients with ovarian cancer using reverse transcriptase-polymerase chain reaction
(RTPCR) and immunohistochemistry. Total RNA from 20 malignant and 10 benign …