[HTML][HTML] Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor γ transactivation
YB Xie, JH Park, DK Kim, JH Hwang, S Oh… - Journal of Biological …, 2009 - ASBMB
SMILE (small heterodimer partner interacting leucine zipper protein) has been identified as
a corepressor of the glucocorticoid receptor, constitutive androstane receptor, and
hepatocyte nuclear factor 4α. Here we show that SMILE also represses estrogen receptor-
related receptor γ (ERRγ) transactivation. Knockdown of SMILE gene expression increases
ERRγ activity. SMILE directly interacts with ERRγ in vitro and in vivo. Domain mapping
analysis showed that SMILE binds to the AF2 domain of ERRγ. SMILE represses ERRγ …
a corepressor of the glucocorticoid receptor, constitutive androstane receptor, and
hepatocyte nuclear factor 4α. Here we show that SMILE also represses estrogen receptor-
related receptor γ (ERRγ) transactivation. Knockdown of SMILE gene expression increases
ERRγ activity. SMILE directly interacts with ERRγ in vitro and in vivo. Domain mapping
analysis showed that SMILE binds to the AF2 domain of ERRγ. SMILE represses ERRγ …