The main trigger for liver injury in acquired cholestatic liver disease remains unclear.
However, the accumulation of bile acids (BAs) undoubtedly plays a role. Recent progress in
deciphering the pathomechanisms of inborn cholestatic liver diseases, decoding
mechanisms of BA-induced cell death, and generating modern BA-derived drugs has
improved the understanding of the regulation of BA synthesis and transport. Now is the
appropriate time to reassess current knowledge about the specific role of BAs in …