Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice
JS Gujral, A Farhood, ML Bajt, H Jaeschke - Hepatology, 2003 - Elsevier
Obstruction of the common bile duct in a variety of clinical settings leads to cholestatic liver
injury. An important aspect of this injury is hepatic inflammation, with neutrophils as the
prominent cell type involved. However, the pathophysiologic role of the infiltrating
neutrophils during cholestatic liver injury remains unclear. Therefore, we tested the
hypothesis that neutrophils contribute to the overall pathophysiology by using bile duct-
ligated (BDL) wild-type animals and mice deficient in the β2 integrin CD18. In wild-type …
injury. An important aspect of this injury is hepatic inflammation, with neutrophils as the
prominent cell type involved. However, the pathophysiologic role of the infiltrating
neutrophils during cholestatic liver injury remains unclear. Therefore, we tested the
hypothesis that neutrophils contribute to the overall pathophysiology by using bile duct-
ligated (BDL) wild-type animals and mice deficient in the β2 integrin CD18. In wild-type …