[HTML][HTML] Genetic inactivation of Kcnj16 identifies Kir5. 1 as an important determinant of neuronal PCO2/pH sensitivity
MC D'Adamo, L Shang, P Imbrici, SDM Brown… - Journal of biological …, 2011 - ASBMB
The molecular identity of ion channels which confer PCO 2/pH sensitivity in the brain is
unclear. Heteromeric Kir4. 1/Kir5. 1 channels are highly sensitive to inhibition by intracellular
pH and are widely expressed in several brainstem nuclei involved in cardiorespiratory
control, including the locus coeruleus. This has therefore led to a proposed role for these
channels in neuronal CO 2 chemosensitivity. To examine this, we generated mutant mice
lacking the Kir5. 1 (Kcnj16) gene. We show that although locus coeruleus neurons from …
unclear. Heteromeric Kir4. 1/Kir5. 1 channels are highly sensitive to inhibition by intracellular
pH and are widely expressed in several brainstem nuclei involved in cardiorespiratory
control, including the locus coeruleus. This has therefore led to a proposed role for these
channels in neuronal CO 2 chemosensitivity. To examine this, we generated mutant mice
lacking the Kir5. 1 (Kcnj16) gene. We show that although locus coeruleus neurons from …