Deletion of Kir5. 1 impairs renal ability to excrete potassium during increased dietary potassium intake
P Wu, ZX Gao, DD Zhang, XT Su… - Journal of the …, 2019 - journals.lww.com
Background The basolateral potassium channel in the distal convoluted tubule (DCT),
comprising the inwardly rectifying potassium channel Kir4. 1/Kir5. 1 heterotetramer, plays a
key role in mediating the effect of dietary potassium intake on the thiazide-sensitive NaCl
cotransporter (NCC). The role of Kir5. 1 (encoded by Kcnj16) in mediating effects of dietary
potassium intake on the NCC and renal potassium excretion is unknown. Methods We used
electrophysiology, renal clearance, and immunoblotting to study Kir4. 1 in the DCT and NCC …
comprising the inwardly rectifying potassium channel Kir4. 1/Kir5. 1 heterotetramer, plays a
key role in mediating the effect of dietary potassium intake on the thiazide-sensitive NaCl
cotransporter (NCC). The role of Kir5. 1 (encoded by Kcnj16) in mediating effects of dietary
potassium intake on the NCC and renal potassium excretion is unknown. Methods We used
electrophysiology, renal clearance, and immunoblotting to study Kir4. 1 in the DCT and NCC …
