Cell mediated cytotoxicity and cytokine production in peripheral blood mononuclear cells of glioma patients
CM Ausiello, C Palma, A Maleci, GC Spagnoli… - European Journal of …, 1991 - Elsevier
A mannoprotein preparation (MP) from Candida albicans induced MHC-unrestricted
cytotoxicity in peripheral blood mononuclear cells (PBMC) from healthy subjects, but not in
those from glioma-bearing subjects. The two groups of subjects did not significantly differ in
the number of cells bearing typical natural killer (NK) markers (both in resting and MP
stimulated PBMC) and NK activity. However, interferon gamma (IFN-γ) production was in
tumour patients minimal or significantly reduced, as compared to healthy subjects, following …
cytotoxicity in peripheral blood mononuclear cells (PBMC) from healthy subjects, but not in
those from glioma-bearing subjects. The two groups of subjects did not significantly differ in
the number of cells bearing typical natural killer (NK) markers (both in resting and MP
stimulated PBMC) and NK activity. However, interferon gamma (IFN-γ) production was in
tumour patients minimal or significantly reduced, as compared to healthy subjects, following …