Experimental therapy of human glioma by means of a genetically engineered virus mutant

RL Martuza, A Malick, JM Markert, KL Ruffner… - Science, 1991 - science.org
RL Martuza, A Malick, JM Markert, KL Ruffner, DM Coen
Science, 1991science.org
Malignant gliomas are the most common malignant brain tumors and are almost always
fatal. A thymidine kinase-negative mutant of herpes simplex virus-1 (dl sptk) that is
attenuated for neurovirulence was tested as a possible treatment for gliomas. In cell culture,
dl sptk killed two long-term human glioma lines and three short-term human glioma cell
populations. In nude mice with implanted subcutaneous and subrenal U87 human gliomas,
intraneoplastic inoculation of dl sptk caused growth inhibition. In nude mice with intracranial …
Malignant gliomas are the most common malignant brain tumors and are almost always fatal. A thymidine kinase-negative mutant of herpes simplex virus-1 (dlsptk) that is attenuated for neurovirulence was tested as a possible treatment for gliomas. In cell culture, dlsptk killed two long-term human glioma lines and three short-term human glioma cell populations. In nude mice with implanted subcutaneous and subrenal U87 human gliomas, intraneoplastic inoculation of dlsptk caused growth inhibition. In nude mice with intracranial U87 gliomas, intraneoplastic inoculation of dlsptk prolonged survival. Genetically engineered viruses such as dlsptk merit further evaluation as novel antineoplastic agents.
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