SUIT, secretory units of islets in transplantation: an index for therapeutic management of islet transplanted patients and its application to type 2 diabetes
Y Yamada, K Fukuda, S Fujimoto, M Hosokawa… - Diabetes research and …, 2006 - Elsevier
Y Yamada, K Fukuda, S Fujimoto, M Hosokawa, K Tsukiyama, K Nagashima, M Fukushima…
Diabetes research and clinical practice, 2006•ElsevierEvaluation of a patient's pancreatic β-cell function is important in both diagnosis and
treatment of diabetes. We sought to determine β-cell function with a single sampling of
blood. Examination of fasting blood glucose (F-BG, mM) and C-peptide (F-CPR, nM) levels
in seven post-islet-transplanted states of four patients revealed a linear relationship between
F-BG and F-CPR. Assuming that normal subjects aged< 40 years have 100% pancreatic β-
cell function, we developed the secretory units of islets in transplantation (SUIT) as an index …
treatment of diabetes. We sought to determine β-cell function with a single sampling of
blood. Examination of fasting blood glucose (F-BG, mM) and C-peptide (F-CPR, nM) levels
in seven post-islet-transplanted states of four patients revealed a linear relationship between
F-BG and F-CPR. Assuming that normal subjects aged< 40 years have 100% pancreatic β-
cell function, we developed the secretory units of islets in transplantation (SUIT) as an index …
Evaluation of a patient's pancreatic β-cell function is important in both diagnosis and treatment of diabetes. We sought to determine β-cell function with a single sampling of blood. Examination of fasting blood glucose (F-BG, mM) and C-peptide (F-CPR, nM) levels in seven post-islet-transplanted states of four patients revealed a linear relationship between F-BG and F-CPR. Assuming that normal subjects aged <40 years have 100% pancreatic β-cell function, we developed the secretory units of islets in transplantation (SUIT) as an index of β-cell function by the formula: 250×F-CPR/(F-BG−3.43). The SUIT index was correlated with the stimulated C-peptide levels not only in islet-transplanted patients (R2=0.68, P<0.05) but also in type 2 patients (R2=0.34, P<0.001). Since the SUIT index can be calculated from data obtained at a single fasting blood sampling and predict the pancreatic β-cell function, the formula may be a useful tool in clinical management of diabetes.
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