[HTML][HTML] The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP
S Fang, S Tsang, R Jones, B Ponugoti, H Yoon… - Journal of biological …, 2008 - ASBMB
The primary bile acid receptor farnesoid X receptor (FXR) maintains lipid and glucose
homeostasis by regulating expression of numerous bile acid-responsive genes, including an
orphan nuclear receptor and metabolic regulator SHP. Using SHP as a model gene, we
studied how FXR activity is regulated by p300 acetylase. FXR interaction with p300 and their
recruitment to the SHP promoter and acetylated histone levels at the promoter were
increased by FXR agonists in mouse liver and HepG2 cells. In contrast, p300 recruitment …
homeostasis by regulating expression of numerous bile acid-responsive genes, including an
orphan nuclear receptor and metabolic regulator SHP. Using SHP as a model gene, we
studied how FXR activity is regulated by p300 acetylase. FXR interaction with p300 and their
recruitment to the SHP promoter and acetylated histone levels at the promoter were
increased by FXR agonists in mouse liver and HepG2 cells. In contrast, p300 recruitment …