Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response
YD Wang, WD Chen, M Wang, D Yu, BM Forman… - Hepatology, 2008 - journals.lww.com
The farnesoid X receptor (FXR) is a nuclear receptor that plays key roles in hepatoprotection
by maintaining the homeostasis of liver metabolism. FXR null mice display strong hepatic
inflammation and develop spontaneous liver tumors. In this report, we demonstrate that FXR
is a negative modulator of nuclear factor κB (NF-κB)–mediated hepatic inflammation.
Activation of FXR by its agonist ligands inhibited the expression of inflammatory mediators in
response to NF-κB activation in both HepG2 cells and primary hepatocytes culturedin vitro …
by maintaining the homeostasis of liver metabolism. FXR null mice display strong hepatic
inflammation and develop spontaneous liver tumors. In this report, we demonstrate that FXR
is a negative modulator of nuclear factor κB (NF-κB)–mediated hepatic inflammation.
Activation of FXR by its agonist ligands inhibited the expression of inflammatory mediators in
response to NF-κB activation in both HepG2 cells and primary hepatocytes culturedin vitro …