Animal model of adenine-induced chronic renal failure in rats
T Yokozawa, PD Zheng, H Oura, F Koizumi - Nephron, 1986 - karger.com
T Yokozawa, PD Zheng, H Oura, F Koizumi
Nephron, 1986•karger.comLong-term feeding of adenine to rats produced metabolic abnormalities resembling chronic
renal failure in humans. Among the disturbances produced were azotemia, accumulation of
uremic toxins, metabolic imbalances of amino acids and electrolytes, and hormonal
imbalances. The pathological findings in the kidneys of these experimental rats revealed
lesions of proximal tubules, of some distal tubules and of glomeruli. Contracted kidneys
were found in the rats with severe perturbations. Our results suggest that long-term adenine …
renal failure in humans. Among the disturbances produced were azotemia, accumulation of
uremic toxins, metabolic imbalances of amino acids and electrolytes, and hormonal
imbalances. The pathological findings in the kidneys of these experimental rats revealed
lesions of proximal tubules, of some distal tubules and of glomeruli. Contracted kidneys
were found in the rats with severe perturbations. Our results suggest that long-term adenine …
Abstract
Long-term feeding of adenine to rats produced metabolic abnormalities resembling chronic renal failure in humans. Among the disturbances produced were azotemia, accumulation of uremic toxins, metabolic imbalances of amino acids and electrolytes, and hormonal imbalances. The pathological findings in the kidneys of these experimental rats revealed lesions of proximal tubules, of some distal tubules and of glomeruli. Contracted kidneys were found in the rats with severe perturbations. Our results suggest that long-term adenine feeding provides a model which would be useful to study chronic renal failure.
Karger