Akt1-mediated fast/glycolytic skeletal muscle growth attenuates renal damage in experimental kidney disease
S Hanatani, Y Izumiya, S Araki… - Journal of the …, 2014 - journals.lww.com
Muscle wasting is frequently observed in patients with kidney disease, and low muscle
strength is associated with poor outcomes in these patients. However, little is known about
the effects of skeletal muscle growth per se on kidney diseases. In this study, we utilized a
skeletal muscle-specific, inducible Akt1 transgenic (Akt1 TG) mouse model that promotes the
growth of functional skeletal muscle independent of exercise to investigate the effects of
muscle growth on kidney diseases. Seven days after Akt1 activation in skeletal muscle, renal …
strength is associated with poor outcomes in these patients. However, little is known about
the effects of skeletal muscle growth per se on kidney diseases. In this study, we utilized a
skeletal muscle-specific, inducible Akt1 transgenic (Akt1 TG) mouse model that promotes the
growth of functional skeletal muscle independent of exercise to investigate the effects of
muscle growth on kidney diseases. Seven days after Akt1 activation in skeletal muscle, renal …