Innate lymphoid cells: new insights into function and development
Current opinion in immunology, 2015•Elsevier
Highlights•Group 1 ILC comprise diverse subsets producing IFN-γ.•Group 2 ILC crosstalk
with TH 2 for immune responses.•Group 3 ILC modulate immune response to the
microbiome and micronutrient status.•Bone marrow progenitors give rise to multiple ILC
lineages.Here, we illustrate the complexity of ILC subsets and discuss novel functions,
focusing on emerging mechanisms of crosstalk with other immune cells and the microbiota.
Furthermore, we highlight recent insights into the development of ILCs, including the …
with TH 2 for immune responses.•Group 3 ILC modulate immune response to the
microbiome and micronutrient status.•Bone marrow progenitors give rise to multiple ILC
lineages.Here, we illustrate the complexity of ILC subsets and discuss novel functions,
focusing on emerging mechanisms of crosstalk with other immune cells and the microbiota.
Furthermore, we highlight recent insights into the development of ILCs, including the …
Highlights
- Group 1 ILC comprise diverse subsets producing IFN-γ.
- Group 2 ILC crosstalk with T H 2 for immune responses.
- Group 3 ILC modulate immune response to the microbiome and micronutrient status.
- Bone marrow progenitors give rise to multiple ILC lineages.
Here, we illustrate the complexity of ILC subsets and discuss novel functions, focusing on emerging mechanisms of crosstalk with other immune cells and the microbiota. Furthermore, we highlight recent insights into the development of ILCs, including the common pathways they share as well as points of divergence between ILC groups and subsets.
Elsevier