Association of traumatic brain injury with late-life neurodegenerative conditions and neuropathologic findings

PK Crane, LE Gibbons, K Dams-O'Connor… - JAMA …, 2016 - jamanetwork.com
Importance The late effects of traumatic brain injury (TBI) are of great interest, but studies
characterizing these effects are limited. Objective To determine whether TBI with loss of
consciousness (LOC) is associated with an increased risk for clinical and neuropathologic
findings of Alzheimer disease (AD), Parkinson disease (PD), and other dementias. Design,
Setting, and Participants This study analyzed data from the Religious Orders Study (ROS),
Memory and Aging Project (MAP), and Adult Changes in Thought study (ACT). All ROS and …