The presence of IL-8+ 781 T/C polymorphism is associated with the parameters of severe Clostridium difficile infection

J Czepiel, G Biesiada, M Dróżdż… - Microbial …, 2018 - Elsevier
Purpose There is large variation in the clinical manifestations of Clostridium difficile infection
(CDI). We also still can not predict which patients are more susceptible to reinfection with
CDI. The aim of our study was to evaluate the effect of gene single nucleotide
polymorphisms (SNP) of proinflammatory cytokines, specifically IL-1β, IL-8 on the
development, clinical course and recurrence of CDI. Methods We performed a prospective
study of adults (130 people≥ 18 years) including 65 patients with CDI treated in tertiary …