[HTML][HTML] Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation
RE Vandenbroucke, I Vanlaere… - Mucosal …, 2014 - Elsevier
Abstract Matrix metalloproteinase 7 (MMP7) is a member of the MMP family. In the small
intestine, MMP7 is responsible for activating α-defensins, which are broad-spectrum anti-
microbial peptides produced by the Paneth cells. We report that MMP7−/− mice are resistant
to LPS-induced lethality and that this resistance is correlated with reduced levels of systemic
cytokines. LPS induced the upregulation and activation of MMP7 in the small intestine,
degranulation of the Paneth cells, and induction of intestinal permeability in MMP7+/+ mice …
intestine, MMP7 is responsible for activating α-defensins, which are broad-spectrum anti-
microbial peptides produced by the Paneth cells. We report that MMP7−/− mice are resistant
to LPS-induced lethality and that this resistance is correlated with reduced levels of systemic
cytokines. LPS induced the upregulation and activation of MMP7 in the small intestine,
degranulation of the Paneth cells, and induction of intestinal permeability in MMP7+/+ mice …
