Matrix metalloproteinase-dependent regulation of extracellular matrix shapes the structure of sexually differentiating mouse gonads
RP Piprek, M Kloc, JZ Kubiak - Differentiation, 2019 - Elsevier
The extracellular matrix (ECM) proteins play an important role in the establishment of the sex-
dependent structure of developing gonads. The matrix metalloproteinases (MMPs) are the
major players in the regulation of ECM. Our hypothesis was that the MMPs-dependent
regulation of EMC is crucial for the establishment of the correct, either testis or ovary,
structure of developing gonad. We cultured developing mouse gonads in vitro in the
presence of the MMPs inhibitors (α-2-macroglobulin, leupeptin, phosphoramidon) or the …
dependent structure of developing gonads. The matrix metalloproteinases (MMPs) are the
major players in the regulation of ECM. Our hypothesis was that the MMPs-dependent
regulation of EMC is crucial for the establishment of the correct, either testis or ovary,
structure of developing gonad. We cultured developing mouse gonads in vitro in the
presence of the MMPs inhibitors (α-2-macroglobulin, leupeptin, phosphoramidon) or the …