Organism burden, toxin concentration, and lactoferrin concentration do not distinguish between clinically significant and nonsignificant diarrhea in patients with …
Clostridium difficile infection is often overdiagnosed in patients with mild diarrhea. We
evaluated 4 biomarkers as surrogates for clinically significant diarrhea (≥ 3 episodes in 24
hours) in 59 PCR-positive patients with and 59 PCR-positive patients without clinically
significant diarrhea. Organism burden (median tcdB cycle threshold value, 26.9 versus 27.1,
P= 0.25) and toxin A and B concentrations (toxin A, median, 0 versus 0 ng/mL, P= 0.42; toxin
B, median, 0 versus 0 ng/mL, P= 0.25) were not significantly different between patients with …
evaluated 4 biomarkers as surrogates for clinically significant diarrhea (≥ 3 episodes in 24
hours) in 59 PCR-positive patients with and 59 PCR-positive patients without clinically
significant diarrhea. Organism burden (median tcdB cycle threshold value, 26.9 versus 27.1,
P= 0.25) and toxin A and B concentrations (toxin A, median, 0 versus 0 ng/mL, P= 0.42; toxin
B, median, 0 versus 0 ng/mL, P= 0.25) were not significantly different between patients with …