[PDF][PDF] A multitargeted, metronomic, and maximum-tolerated dose “chemo-switch” regimen is antiangiogenic, producing objective responses and survival benefit in a …
Purpose A transgenic mouse model has revealed parameters of the angiogenic switch
during multistep tumorigenesis of pancreatic islets, and demonstrated efficacy of
antiangiogenic therapies. Pericytes have been revealed as functionally important for tumor
neovasculature, using kinase inhibitors targeting their platelet-derived growth factor
receptors (PDGFRs). Additionally, vascular endothelial growth factor receptor (VEGFR)
inhibitors and metronomic chemotherapy show modest benefit against early-but not late …
during multistep tumorigenesis of pancreatic islets, and demonstrated efficacy of
antiangiogenic therapies. Pericytes have been revealed as functionally important for tumor
neovasculature, using kinase inhibitors targeting their platelet-derived growth factor
receptors (PDGFRs). Additionally, vascular endothelial growth factor receptor (VEGFR)
inhibitors and metronomic chemotherapy show modest benefit against early-but not late …
Purpose
A transgenic mouse model has revealed parameters of the angiogenic switch during multistep tumorigenesis of pancreatic islets, and demonstrated efficacy of antiangiogenic therapies. Pericytes have been revealed as functionally important for tumor neovasculature, using kinase inhibitors targeting their platelet-derived growth factor receptors (PDGFRs). Additionally, vascular endothelial growth factor receptor (VEGFR) inhibitors and metronomic chemotherapy show modest benefit against early-but not late-stage disease.
Citeseer