[HTML][HTML] Nitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent γH2AX protein formation in pancreatic β cells
BJ Oleson, KA Broniowska, KH Schreiber… - Journal of Biological …, 2014 - ASBMB
In this study, the effects of cytokines on the activation of the DNA double strand break repair
factors histone H2AX (H2AX) and ataxia telangiectasia mutated (ATM) were examined in
pancreatic β cells. We show that cytokines stimulate H2AX phosphorylation (γH2AX
formation) in rat islets and insulinoma cells in a nitric oxide-and ATM-dependent manner. In
contrast to the well documented role of ATM in DNA repair, ATM does not appear to
participate in the repair of nitric oxide-induced DNA damage. Instead, nitric oxide-induced …
factors histone H2AX (H2AX) and ataxia telangiectasia mutated (ATM) were examined in
pancreatic β cells. We show that cytokines stimulate H2AX phosphorylation (γH2AX
formation) in rat islets and insulinoma cells in a nitric oxide-and ATM-dependent manner. In
contrast to the well documented role of ATM in DNA repair, ATM does not appear to
participate in the repair of nitric oxide-induced DNA damage. Instead, nitric oxide-induced …