[HTML][HTML] Clarifying the function of genes at the chromosome 16p13 locus in type 1 diabetes: CLEC16A and DEXI
MA Gingerich, V Sidarala, SA Soleimanpour - Genes & Immunity, 2020 - nature.com
MA Gingerich, V Sidarala, SA Soleimanpour
Genes & Immunity, 2020•nature.comMore than a decade after the discovery of a novel type 1 diabetes risk locus on chromosome
16p13, there remains complexity and controversy over the specific gene (s) that regulate
diabetes pathogenesis. A new study by Nieves-Bonilla et al. shows that one of these genes,
DEXI, is unlikely to contribute to type 1 diabetes pathogenesis and positions the
endolysosomal E3 ubiquitin ligase CLEC16A as the primary culprit by which this gene locus
influences diabetes risk.
16p13, there remains complexity and controversy over the specific gene (s) that regulate
diabetes pathogenesis. A new study by Nieves-Bonilla et al. shows that one of these genes,
DEXI, is unlikely to contribute to type 1 diabetes pathogenesis and positions the
endolysosomal E3 ubiquitin ligase CLEC16A as the primary culprit by which this gene locus
influences diabetes risk.
Abstract
More than a decade after the discovery of a novel type 1 diabetes risk locus on chromosome 16p13, there remains complexity and controversy over the specific gene(s) that regulate diabetes pathogenesis. A new study by Nieves-Bonilla et al. shows that one of these genes, DEXI, is unlikely to contribute to type 1 diabetes pathogenesis and positions the endolysosomal E3 ubiquitin ligase CLEC16A as the primary culprit by which this gene locus influences diabetes risk.
nature.com