Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro
C Pirazzi, M Adiels, MA Burza, RM Mancina… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: The robust association between non-alcoholic fatty liver disease
(NAFLD) and the genetic variant I148M (rs738409) in PNPLA3 has been widely replicated.
The aim of this study was to investigate the effect of the PNPLA3 I148M mutation on:(1)
hepatic secretion of very low density lipoproteins (VLDL) in humans; and (2) secretion of
apolipoprotein B (apoB) from McA-RH 7777 cells, which secrete VLDL-sized apoB-
containing lipoproteins. METHODS: VLDL kinetics was analyzed after a bolus infusion of …
(NAFLD) and the genetic variant I148M (rs738409) in PNPLA3 has been widely replicated.
The aim of this study was to investigate the effect of the PNPLA3 I148M mutation on:(1)
hepatic secretion of very low density lipoproteins (VLDL) in humans; and (2) secretion of
apolipoprotein B (apoB) from McA-RH 7777 cells, which secrete VLDL-sized apoB-
containing lipoproteins. METHODS: VLDL kinetics was analyzed after a bolus infusion of …