TM6SF2: A novel target for plasma lipid regulation
TT Li, TH Li, J Peng, B He, LS Liu, DH Wei, ZS Jiang… - Atherosclerosis, 2018 - Elsevier
Abstract Transmembrane 6 superfamily 2 (TM6SF2), a gene identified at the locus 19p12,
has been recognized to regulate plasma lipids. Here, we provide an overview of the roles of
TM6SF2 as a novel target for plasma lipid regulation. We first review the association of
TM6SF2 variant with plasma lipid traits, cardiovascular disease (CVD) and non-alcoholic
fatty liver disease (NAFLD). Then, we present an overview about the in vivo validation of
TM6SF2 as a regulator of plasma lipid levels using mice, with overexpression or …
has been recognized to regulate plasma lipids. Here, we provide an overview of the roles of
TM6SF2 as a novel target for plasma lipid regulation. We first review the association of
TM6SF2 variant with plasma lipid traits, cardiovascular disease (CVD) and non-alcoholic
fatty liver disease (NAFLD). Then, we present an overview about the in vivo validation of
TM6SF2 as a regulator of plasma lipid levels using mice, with overexpression or …